Department of Health and Social Care (DHSC) has issued a medicine supply notification for Diamorphine 5mg, 10mg and 100mg powder for solution for injection ampoules.
MSN/2025/071
Tier 3 – High impact
Date of issue: 23 December 2025
- Diamorphine 5 mg and 10 mg powder for solution for injection ampoules are currently out of stock, with no confirmed resupply date.
- Diamorphine 100 mg powder for solution for injection ampoules are expected to become unavailable from early January, with no currently confirmed resupply date.
- Diamorphine 30mg powder for solution for injection ampoules are currently available but are unable to support any increase in demand.
- Morphine sulfate injection has been identified by clinical experts as the first-line alternative opioid.
- Sufficient supplies of morphine sulfate 10mg/ml injection are available from Ethypharm and Hameln to cover the supply gap.
- During previous shortages of diamorphine, both primary and secondary care organisations were advised to switch to morphine, where clinically appropriate. This should be expedited as a permanent change in practice given the continuing unpredictable supply of diamorphine.
A copy of this medicine supply notification, including supporting information, has been sent to all pharmacy NHS email addresses.
DHSC and NHS England have launched an online Medicines Supply Tool, which provides up-to-date information about medicine supply issues. The contents of these MSNs can now be viewed on the Tool.
The Tool also details any changes to resupply dates and updates to the entries.
To access the Tool you will need an NHS email address. Once set up and logged in, you will be able to access it online.
New shortages not listed on the SPS website, can be reported using our shortage reporting tool.
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